celsr2 protein expression overview (Human Protein Atlas)
90
Structured Review
Human Protein Atlas
celsr2 protein expression overview
Celsr2 Protein Expression Overview, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/celsr2 protein expression overview/product/Human Protein Atlas
Average 90 stars, based on 1 article reviews
Celsr2 Protein Expression Overview, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/celsr2 protein expression overview/product/Human Protein Atlas
Average 90 stars, based on 1 article reviews
celsr2 protein expression overview - by Bioz Stars,
2026-05
90/100 stars
Images
1) Product Images from "Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma"
Article Title: Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma
Journal: BMC Cancer
doi: 10.1186/s12885-020-06813-5
Figure Legend Snippet: Gene and protein expression profiles of CELSR2 in human normal and tumor samples. a CELSR2 mRNA expression data from the GTEx project in the Human Protein Atlas. b CELSR2 gene expression in common human tumor tissues in the Human Protein Atlas. c CELSR2 protein expression overview in human tumor tissues in the Human Protein Atlas. d CELSR2 mRNA expression overview in human cancer cell lines in the Human Protein Atlas
Techniques Used: Expressing, Gene Expression
Figure Legend Snippet: Gene expression profiles of CELSR2 in the HCCDB database. a Radar map of CELSR2 overall expression among different types of tissues. b The differential expression of CELSR2 in different liver cancer datasets (HCCDB1, HCCDB3, HCCDB4, HCCDB6, HCCDB7, HCCDB13, HCCDB15, HCCDB17 and HCCDB18) suggests that CELSR2 expression is much higher in HCC tissues than in adjacent liver tissues. The coexpression networks of CELSR2 in HCC tissues ( c ), adjacent liver tissues ( d ) and normal tissues from the GTEx project ( e ) showed that different liver tissues expressed different coexpression networks
Techniques Used: Gene Expression, Expressing, Quantitative Proteomics
Figure Legend Snippet: The mRNA expression of CELSR2 in the UALCAN database. a The mRNA expression level of CELSR2 was significantly higher in cancer tissues than in normal tissues. b The expression level of CELSR2 in female patients was higher than that in healthy people or in male patients. c Patients (age > 21 years old) commonly had higher gene expression than young healthy people. The expression level of CELSR2 was positively correlated with patient weight ( d ), tumor stage ( e ) and tumor grade ( f ) in HCC patients. *** represents p < 0.001
Techniques Used: Expressing, Gene Expression
Figure Legend Snippet: Gene expression of CELSR2 and its prognostic value in HCC patients. a Prognostic value of the CELSR2 level in HCC patients from the Human Protein Atlas. b Representative immunohistochemistry (IHC) images from the Human Protein Atlas with the CELSR2 antibody: HPA013952, cancerous tissue had higher staining than that in normal liver tissue. c High CELSR2 mRNA expression was significantly related to poor OS in HCC patients from the Kaplan-Meier plotter
Techniques Used: Gene Expression, Immunohistochemistry, Staining, Expressing
Figure Legend Snippet: Genetic mutations of CELSR2 and its associations with OS in HCC patients (cBioPortal). a Oncoprint of CELSR2 alterations in HCC. The overview of genomic alterations showed that the alteration rate of CELSR2 was 8%. b Mutation types of CELSR2 gene in HCC patients. c Network view of CELSR2 and its altered neighboring genes in HCC. d GO functional enrichment and KEGG pathway analyses of CELSR2 and its frequently altered neighboring genes
Techniques Used: Mutagenesis, Functional Assay
Figure Legend Snippet: Genes differentially expressed in correlation with CELSR2 in HCC (LinkedOmics). a Volcano plot showing genes correlated with CELSR2 through Pearson’s test analysis. b, c Heat maps showing the top 50 genes positively and negatively correlated with CELSR2in HCC; red (positive), green (negative). The significantly enriched GO annotations ( d ) cellular components, ( e ) biological processes and ( f ) molecular functions), KEGG pathways ( g ), kinase ( h ), miRNA ( i ) and transcription factor ( j ) targets of CELSR2 coexpressed genes in HCC were analyzed using GSEA
Techniques Used:
Figure Legend Snippet: Expression and biological function of CELSR2 in HCC. a The mRNA and protein levels of CELSR2 from cultured cells by qPCR and western blot assays. The expression of CELSR2 protein was normalized to GAPDH. b, c CELSR2 knockdown prohibited the proliferation rate of hepatoma cells. d-k CELSR2 knockdown reduced cell invasion in both HepG2 and Hep3B cells. l Representative cases of high and low CELSR2 expression by immunohistochemistry staining. m Semi-quantitative analysis of CELSR2 protein expression between cancerous specimens and non-cancerous parts. * represents p < 0.05, *** represents p < 0.01, *** represents p < 0.001
Techniques Used: Expressing, Cell Culture, Western Blot, Knockdown, Immunohistochemistry, Staining
Figure Legend Snippet: Prognostic factors associated with recurrence-free survival
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Figure Legend Snippet: Prognostic factors associated with overall survival
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